Pharmacologic suppression of intimal hyperplasia
نویسندگان
چکیده
منابع مشابه
A Novel Approach against Vascular Intimal Hyperplasia Through the Suppression of Girdin.
Intimal hyperplasia is an impediment to patency in both arteries after percutaneous angioplasty (PTA) and veingraft. It is well known that migration and proliferation of vascular smooth muscle cells (SMCs) influence the vascular remodeling process, there are no therapies to prevent intimal hyperplasia of post-PTA arteries and vein grafts. Girdin (girders of actin filaments), also known as Gα-in...
متن کاملNeo-intimal hyperplasia, diabetes and endovascular injury
Diabetes is a significant major risk factor for peripheral arterial disease (PAD) and critical limb ischaemia (CLI), the latter which is also the most common cause of amputation in these patients. Revascularisation of the lower extremities of such patients is imperative for limb salvage and has become First-line therapy. However, the incidence of restenosis following endovascular stenting is ve...
متن کاملAngiogenesis-dependent and independent phases of intimal hyperplasia.
BACKGROUND Neointimal vascular smooth muscle cell (VSMC) proliferation is a primary cause of occlusive vascular disease, including atherosclerosis, restenosis after percutaneous interventions, and bypass graft stenosis. Angiogenesis is implicated in the progression of early atheromatous lesions in animal models, but its role in neointimal VSMC proliferation is undefined. Because percutaneous co...
متن کاملEffect of Anastomotic Method on Intimal Hyperplasia in Rabbit Aorta
Purpose: The clinical advantages of end-to-end (ETE) anastomosis have not been clear despite its biomechanical advantage over end-to-side (ETS) anastomosis. We compared the histomorphometric features of intimal remodeling after ETE and ETS anastomosis in a rabbit aortic bypass model. Methods: Thirty-two bypass operations, 16 with ETS and 16 with ETE anastomoses, were performed using aortic allo...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 1994
ISSN: 0741-5214
DOI: 10.1016/0741-5214(94)90247-x